Clinical effects of hydrogen administration: From animal and human diseases to exercise medicine
“There are no safety issues with hydrogen; it has been used for years in gas mixtures for deep diving and in numerous clinical trials without adverse events, and there are no warnings in the literature of its toxicity or long term exposure effects.”
Nicolson, G. L., Mattos, G. F., Settineri, R., Costa, C., Ellithorpe, R., Rosenblatt, S., … Ohta, S. (2016). International Journal of Clinical Medicine, 7(1), 32–76. https://doi.org/10.4236/ijcm.2016.71005
Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT
“If too much hydrogen is taken in, the excess would be expired through the lungs. Thus, hydrogen-rich water has great potential for clinical use.”
Kitamura, A., Kobayashi, S., Matsushita, T., Fujinawa, H., & Murase, K. (2010). The British Journal of Radiology, 83(990), 509–514. https://doi.org/10.1259/bjr/25604811
Hydrogen-rich water exerting a protective effect on ovarian reserve function in a mouse model of immune premature ovarian failure induced by zona pellucida 3
“Hydrogen has not been reported to be toxic at high doses, because excess hydrogen is expired via the lungs into the air.”
Ma, Y., He, X., Wang, S., Yin, C., Wang, T., & Jia, C. (2016). Chinese Medical Journal, 129(9), 2331–2337. https://doi.org/10.4103/0366-6999.190668
Estimation of the hydrogen concentration in rat tissue following administration via various routes
“Hydrogen has not been reported to be toxic at effective doses, and overdoses are unlikely, as excess hydrogen is expired via the lungs.”
Liu, C., Kurokawa, R., Fujino, M., Hirano, S., Sato, B., & Li, X. (2014). Scientific Reports, 4, 5485. https://doi.org/10.1038/srep05485
Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap
“H₂ can reach relatively high concentrations quickly, and excessive H₂ can be eliminated from the body via breathing, causing no side effects.”
Zhao, L., Wang, Y., Qin, S., Ma, X., Sun, X., Wang, M., & Zhong, R. (2013). Journal of Zhejiang University Science B, 14(5), 382–391. https://doi.org/10.1631/jzus.B1200317
Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice
“H₂ has a potential as a novel radioprotector without known toxic side effects… with no side effects.”
Chuai, Y., Gao, F., Li, B., Zhao, L., Qian, L., Cao, F., … Cai, J. (2012). Biochemical Journal, 442(1), 49–56. https://doi.org/10.1042/BJ20111786
Hydrogen-rich water improves neurological functional recovery in EAE mice
“Because hydrogen-rich water is non-toxic, inexpensive, easily administered, and can readily cross the blood–brain barrier, our experiments suggest HRW may have great potential…”
Zhao, M., Liu, M., Pu, Y., Wang, D., Xie, Y., Xue, G., … Cao, L. (2016). Journal of Neuroimmunology, 294, 6–13. https://doi.org/10.1016/j.jneuroim.2016.03.006
Hydrogen-rich water affected blood alkalinity in physically active men
“No participants reported any vexatious side effects of H₂ supplementation… HRW administration is safe…”
Ostojic, S. M., & Stojanovic, M. D. (2014). Research in Sports Medicine, 22(1), 49–60. https://doi.org/10.1080/15438627.2013.852092
Hydrogen-rich saline as an innovative therapy for cataract: A hypothesis
“Hydrogen as a natural molecule could be a safe and effective antioxidant without known toxic effects.”
Qin, L., Tao, Y., Wang, L., Chen, H., Liu, Y., & Huang, Y. F. (2016). Medical Science Monitor, 22, 3191–3195. https://doi.org/10.12659/MSM.899807
Recent progress toward hydrogen medicine
“H₂ has no cytotoxicity even at high concentration.”
Ohta, S. (2011). Current Pharmaceutical Design, 17(22), 2241–2252. https://doi.org/10.2174/138161211797052664
Hydrogen therapy attenuates irradiation-induced lung damage
“H₂ treatment is valuable for protection against irradiation lung damage with no known toxicity.”
Terasaki, Y., Ohsawa, I., Terasaki, M., Takahashi, M., Kunugi, S., Dedong, K., … Fukuda, Y. (2011). AJP – Lung, 301(4), L415–L426. https://doi.org/10.1152/ajplung.00008.2011
Hydrogen-rich saline attenuates steroid-associated femoral head necrosis
“No side effects of the hydrogen-rich saline… were observed in either group.”
Huang, S., Jiao, J., & Yan, H. (2015). Experimental and Therapeutic Medicine, 11(1), 177–182. https://doi.org/10.3892/etm.2015.2883
Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain in rats
“HRS has the following advantages: easy to use, no side effects and no tolerance develops when given continuously…”
Ge, Y., Wu, F., Sun, X., Xiang, Z., Yang, L., Huang, S., … Yu, W. (2014). PLOS ONE, 9(5), e97436. https://doi.org/10.1371/journal.pone.0097436
Hydrogen-rich water decreases serum LDL and improves HDL function
“We did not observe any unwanted side effects of H₂…”
Song, G., Li, M., Sang, H., Zhang, L., Li, X., Yao, S., … Qin, S. (2013). Journal of Lipid Research, 54(7), 1884–1893. https://doi.org/10.1194/jlr.M036640
Effects of hydrogen-rich water on depressive-like behavior in mice
“Hydrogen-rich water, which has no known side effects, may have beneficial effects in mitigating depression symptoms.”
Zhang, Y., Su, W., Chen, Y., Wu, T., Gong, H., Shen, X., … Jiang, C. (2016). Scientific Reports, 6, 23742. https://doi.org/10.1038/srep23742
